![](/ServeContent?url=http%3A%2F%2Farchfami.ama-assn.org%2Ficons%2Fspacer.gif) |
![](/ServeContent?url=http%3A%2F%2Farchfami.ama-assn.org%2Ficons%2Fspacer.gif) |
![](/ServeContent?url=http%3A%2F%2Farchfami.ama-assn.org%2Ficons%2Fspacer.gif)
Practical Management of OsteoarthritisIntegration of Pharmacologic and Nonpharmacologic Measures
Marie R. Griffin, MD, MPH;
Kenneth D. Brandt, MD;
Matthew H. Liang, MD, MPH;
Theodore Pincus, MD;
Wayne A. Ray, PhD
Arch Fam Med. 1995;4(12):1049-1055.
References Article references have been provided for searching and linking. Additional reference information may be available in the article PDF.
![](/ServeContent?url=http%3A%2F%2Farchfami.ama-assn.org%2Ficons%2Fspacer.gif) | ![](/ServeContent?url=http%3A%2F%2Farchfami.ama-assn.org%2Ficons%2Fspacer.gif) |
1. Tomita DK, Baum C, Kennedy DL, Knapp DE, Perry ZA. Drug Utilization in the United States: 1987 Ninth Annual Review. Washington, DC: US Dept of Health and Human Services; 1988.
2. Tomita DK, Kennedy DL, Baum C, Knapp DE, Anello C. Drug Utilization in the United States: 1988 Tenth Annual Review. Washington, DC: US Dept of Health and Human Services; 1989. 3. Burke LB, Baum C, Jolson HM, Kennedy DL. Drug Utilization in the United States: 1989 Eleventh Annual Review. Washington, DC: US Dept of Health and Human Services; 1991. 4. Peyron JG, Altman RD. The epidemiology of osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, eds. Osteoarthritis: Diagnosis and Medical/Surgical Management. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1992: 15-37. 5. Ray WA, Griffin MR, Shorr RI. Adverse drug reactions and the elderly. Health Aff (Millwood). 1990;9:114-122.
PUBMED
6. Pincus T, Griffin M. Gastrointestinal disease associated with nonsteroidal antiinflammatory drugs: new insights from observational studies and functional status questionnaires. Am J Med. 1991;91:209-212.
PUBMED
7. Batchlor EE, Paulus HE. Principles of drug therapy. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, eds. Osteoarthritis: Diagnosis and Medical/Surgical Management. 2nd ed. Philadelphia, Pa: WB Saunders Co; 1992: 465-492. 8. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan S. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med. 1991;325:87-91.
ABSTRACT
9. Griffin MR, Ray WA, Schaffner W. Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med. 1988;109:359-363.
FREE FULL TEXT
10. Collier DS, Pain JA. Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. Gut. 1985;26:359-363.
FREE FULL TEXT
11. Mclntosh JH, Byth K, Piper DW. Environmental factors in aetiology of chronic gastric ulcer: a case control study of exposure variables before the first symptoms. Gut. 1985;28:789-798.
12. Somerville K, Faulkner G, Langmen M. Nonsteroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet. 1986;1:462-464.
PUBMED
13. Duggan JM, Dobson AJ, Johnson H, Fahey P. Peptic ulcer and non-steroidal antiinflammatory agents. Gut. 1986;27:929-933.
FREE FULL TEXT
14. Clinch D, Banerjee AK, Levy DW, Ostick G, Faragher EB. Nonsteroidal anti-inflammatory drugs and peptic ulceration. J R Coll Physicians Lond. 1987;21:183-187.
PUBMED
15. Armstrong CP, Blower AL. Non-steroidal anti-inflammatory drugs, and life threatening complications of peptic ulceration. Gut. 1987;28:527-532.
FREE FULL TEXT
16. Guess HA, West R, Strand LM, et al. Fatal upper gastrointestinal hemorrhage or perforation among users and non-users of non-steroidal anti-inflammatory drugs in Saskatchewan Canada, 1983. J Clin Epidemiol. 1988;41:35-45.
PUBMED
17. Mclntosh JH, Fung CS, Berry C, Piper DW. Smoking, nonsteroidal anti-inflammatory drugs, and acetaminophen in gastric ulcer: a study of associations and of the effects of previous diagnosis on exposure patterns. Am J Epidemiol. 1988;128:761-770.
FREE FULL TEXT
18. Griffin MR, Piper JM, Daugherty JR, Snowden M, Ray WA. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Ann Intern Med. 1991;114:257-263.
FREE FULL TEXT
19. Morris AJ, Madhok R, Sturrock RD, Capell HA, MacKenzie JF. Enteroscopic diagnosis of small bowel ulceration in patients receiving nonsteroidal anti-inflammatory drugs. Lancet. 1991;337:520.
PUBMED
20. Bjarnason I, Prouse P, Smith T, et al. Blood and protein loss via small-intestinal inflammation induced by non-steroidal antiinflammatory drugs. Lancet. 1987;26:711-714.
21. Langman MJS, Morgan L, Worrall A. Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. BMJ. 1985;290:347-349.
FREE FULL TEXT
22. Campbell K, Steele RJC. Non-steroidal anti-inflammatory drugs and complicated diverticular disease: a case-control study. Br J Surg. 1991;78:190-191.
PUBMED
23. Brater DC, Anderson S, Baird B, Campbell WB. Effects of ibuprofen, naproxen, and sulindac on prostaglandins in men. Kidney Int. 1985;27:66-73.
PUBMED
24. Brater DC, Anderson SA, Brown-Cartwright D, Toto RD. Effects of nonsteroidal anti-inflammatory drugs on renal function in patients with renal insufficiency and in cirrhotics. Am J Kidney Dis. 1986;5:351-355.
25. Brater DC. Clinical aspects of renal prostaglandins and NSAID therapy. Semin Arthritis Rheum. 1988;17:17-22.
PUBMED
26. Kleinknecht D, Landais P, Goldfarb B. Analgesic and non-steroidal anti-inflammatory drugassociated acute renal failure: a prospective collaborative study. Clin Nephrol. 1986;25:275-281.
PUBMED
27. Stillman MT, Schlesinger PA. Nonsteroidal anti-inflammatory drug nephrotoxicity: should we be concerned? Arch Intern Med. 1990;150:568-570.
28. Gay GR. Another side effect of NSAIDs. JAMA. 1990;264:2677-2678.
FREE FULL TEXT
29. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med. 1994;331:1272-1285.
FREE FULL TEXT
30. Wong DG, Lamki L, Spence JD, Freeman D, McDonald JWD. Effects of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics. Lancet. 1986;3:997-1001.
31. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs. Ann Intern Med. 1987;107:628-635.
FREE FULL TEXT
32. Smalley WE, Ray WA, Daugherty J, Griffin MR. Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons. Am J Epidemiol. 1995;141:539-545.
FREE FULL TEXT
33. Graves EJ, Kozak LJ. National Hospital Discharge Survey: Annual Summary, 1990. Washington, DC: National Center for Health Statistics; 1992. Vital and Health Statistics, Series 13, No. 12; DHHS publication (PHS) 92-1773. 34. Garcia Rodriguez LA, Walker AM, Gutthann SP. Nonsteroidal antiinflammatory drugs and gastrointestinal hospitalizations in Saskatchewan: a cohort study. Epidemiology. 1992;3:337-342.
PUBMED
35. Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis. Ann Intern Med. 1991;115:787-796.
FREE FULL TEXT
36. The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. N Engl J Med. 1990;323:1505-1511.
ABSTRACT
37. Stroke Prevention in Atrial Fibrillation investigators. Stroke Prevention in Atrial Fibrillation Study: final results. Circulation. 1991;84:527-539.
FREE FULL TEXT
38. Kutner M, Nixon G, Silverstone F. Physicians' attitudes toward oral anticoagulants and anti-platelet agents for stroke prevention in elderly patients with atrial fibrillation. Arch Intern Med. 1991;151:1950-1953.
FREE FULL TEXT
39. Piper JM, Ray WA, Daugherty JR, Griffin MR. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med. 1991;114:735-740.
FREE FULL TEXT
40. Shorr RI, Ray WA, Daugherty JR, Griffin MR. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med. 1993;153:1665-1670.
FREE FULL TEXT
41. Ehsanullah RSB, Page MC, Tildesley G, Wood JR. Prevention of gastroduedenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial ranitidine. BMJ. 1988;297:1017-1021.
FREE FULL TEXT
42. Graham DY, Agrawal NM, Roth SH. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet. 1988;2:1277-1280.
PUBMED
43. Edelson JT, Tosteson ANA, Sax P. Cost-effectiveness of misoprostol for prophylaxis against nonsteroidal anti-inflammatory druginduced gastrointestinal tract bleeding. JAMA. 1990;264:41-47.
FREE FULL TEXT
44. Hillman AL, Bloom BS. Economic effects of prophylactic use of misoprostol to prevent gastric ulcer in patients taking nonsteroidal anti-inflammatory drugs. Arch Intern Med. 1989;149:2061-2065.
FREE FULL TEXT
45. Knill-Jones R, Drummond M, Kohli H, Davies L. Economic evaluation of gastric ulcer prophylaxis in patients with arthritis receiving nonsteroidal anti-inflammatory drugs. Postgrad Med J. 1990;66:639-646.
FREE FULL TEXT
46. Stucki G, Johannesson M, Liang MH. Is misoprostol cost-effective in the prevention of nonsteroidal anti-inflammatory drug-induced gastropathy in patients with chronic arthritis? Arch Intern Med. 1994;154:2020-2025.
FREE FULL TEXT
47. Puett DW, Griffin MR. Published trials of non-medicinal and noninvasive therapies for hip and knee osteoarthritis. Ann Intern Med. 1994;121:133-140.
FREE FULL TEXT
48. Brandt KD. Nonsurgical management of osteoarthritis, with an emphasis on nonpharmacologic measures. Arch Fam Med. 1995;4:1057-1064.
FREE FULL TEXT
49. Weinberger M, Tierney WM, Booher P, Katz BP. Can the provision of information to patients with osteoarthritis improve functional status? a randomized controlled trial. Arthritis Rheum. 1989;32:1577-1583.
PUBMED
50. Mullen PD, Laville EA, Biddle AK, Lorig K. Efficacy of psychoeducational interventions on pain, depression, and disability in people with arthritis: a meta-analysis. J Rheumatol. 1987;14:33-39.
PUBMED
51. Lorig K, Lubeck D, Kraines RG, Seleznick M, Holman HR. Outcomes of self-help education for patients with arthritis. Arthritis Rheum. 1985;28:680-685.
PUBMED
52. Weinberger M, Tierney WM, Cowper PA, Katz BP, Booher PA. Cost-effectiveness of increased telephone contact for patients with osteoarthritis. Arthritis Rheum. 1993;36:243-246.
PUBMED
53. Lorig KR, Mazonson PD, Holman HR. Evidence suggesting that health education for self-management in patients with chronic arthritis has sustained health benefits while reducing health care costs. Arthritis Rheum. 1993;36:439-446.
PUBMED
54. Brooks PM, Day RO. Nonsteroidal antiinflammatory drugs: differences and similarities. N Engl J Med. 1991;324:1716-1725.
PUBMED
55. Deal CL, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD. Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther. 1991;13:383-395.
PUBMED
56. McCarthy GM, McCarty DJ. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J Rheumatol. 1992;19:604-607.
PUBMED
57. Altman RD, Aven A, Holmburg CE, Pfeifer LM, Sack M, Young GT. Capsaicin cream 0.025% as monotherapy for osteoarthritis: a doubleblind study. Arthritis Rheum. 1994;23(suppl_3):25-33.
58. Algozzine GJ, Stein GH, Doering PL, Araujo OE, Akin KC. Trolamine salicylate cream in osteoarthritis of the knee. JAMA. 1982;247:1311-1313.
FREE FULL TEXT
59. O'Brien WM. Trolamine salicylate cream in osteoarthritis. JAMA. 1982;248:1577-1578.
FREE FULL TEXT
60. Doogan DP. Topical NSAIDs: a gimmick or a godsend? Lancet. 1989;2:779-780.
PUBMED
61. Amadio P Jr, Cummings DM. Evaluation of acetaminophen in the management of osteoarthritis of the knee. Curr Ther Res. 1983;34:59-66.
62. Calin A. Pain and inflammation. Am J Med. 1984;77(3A):9-15.
PUBMED
63. Steele K, Mills KA, Gilliland AEW, Irwin WG, Taggart A. Repeat prescribing of non-steroidal anti-inflammatory drugs excluding aspirin: how careful are we? BMJ. 1987;295:962-964.
FREE FULL TEXT
64. Quinet RJ. Osteoarthritis: increasing mobility and reducing disability. Geriatrics. 1986;41:36-50.
PUBMED
65. Pinals RS. Pharmacologic treatment of osteoarthritis. Clin Ther. 1992;14:336-346.
PUBMED
66. Hugenberg ST, Myers SL, Brandt KD, Ryan S. Synovitis does not predict response to nonsteroidal antiinflammatory drug therapy in knee osteoarthritis. Arthritis Rheum. 1991;34(suppl):S84.
67. Dieppe PA, Frankel SJ, Toth B. Is research into the treatment of osteoarthritis with nonsteroiodal anti-inflammatory drugs misdirected? Lancet. 1993;341:353-354.
PUBMED
68. Jackson CH, MacDonald NC, Cornett JWD. Acetaminophen: a practical pharmacologic overview. Can Med Assoc J. 1984;131:25-32.
ABSTRACT
69. Stamp J, Rhind V, Haslock I. A comparison of nefopam and flurbiprofen in the treatment of osteoarthrosis. Br J Clin Pract. 1989;43:24-26.
PUBMED
70. Parr G, Darekar B, Fletcher A, Bulpitt CJ. Joint pain and quality of life: results of a randomised trial. Br J Clin Pharmacol. 1989;27:235-242.
PUBMED
71. Doyle DV, Dieppe PA, Scott J, Huskisson EC. An articular index for the assessment of osteoarthritis. Ann Rheum Dis. 1981;40:75-78.
FREE FULL TEXT
72. Williams HJ, Ward JR, Egger MJ, et al. Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee. Arthritis Rheum. 1993;36:1196-1206.
PUBMED
73. Dieppe P, Cushnaghan J, Jasani MK, McCrae F, Watt I. A two-year, placebo-controlled trial of non-steroidal anti-inflammatory therapy in osteoarthritis of the knee joint. Br J Rheumatol. 1993;32:595-600.
FREE FULL TEXT
74. Farrell GC. The hepatic side-effects of drugs. Med J Aust. 1986;145:600-604.
PUBMED
75. Denison H, Kaczynski J, Wallerstedt S. Paracetamol medication and alcohol abuse: a dangerous combination for the liver and the kidney. Scand J Gastroenterol. 1987;22:701-704.
PUBMED
76. Whitcomb DA, Block GD. Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA. 1994;272:1845-1850.
FREE FULL TEXT
77. Sandler DP, Smith JC, Weinberg CR, et al. Analgesic use and chronic renal disease. N Engl J Med. 1989;320:1238-1243.
ABSTRACT
78. Perneger TV, Whelton PK, Klag MJ. Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs. N Engl J Med. 1994;331:1675-1679.
FREE FULL TEXT
79. Sandler DP, Burr FR, Weinberg CR. Nonsteroidal anti-inflammatory drugs and risk of chronic renal disease. Ann Intern Med. 1991;115:165-172.
PUBMED
80. Beaver WT. Combination analgesics. Am J Med. 1984;9:38-53.
81. Shorr RI, Griffin MR, Daugherty JR, Ray WA. Opioid analgesics and the risk of hip fracture in the elderly: codeine and propoxyphene. J Gerontol. 1992;47:M111-M115.
ABSTRACT
82. Kjaersgaard-Andersen P, Naefei A, Skov O, et al. Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. Pain. 1990;43:309-318.
PUBMED
83. Boissier C, Perpoint B, Laporte-Simitsidis S, et al. Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis. J Clin Pharmacol. 1992;32:990-995.
FREE FULL TEXT
84. Dieppe PA, Sathapatayavongs B, Jones HE, Bacon PA, Ring EFJ. Intra-articular steroids in osteoarthritis. Rheumatol Rehabil. 1980;19:212-217.
PUBMED
85. Friedman DM, Moore ME. The efficacy of intraarticular steroids in osteoarthritis: a double-blind study. J Rheumatol. 1980;7:850-856.
PUBMED
86. Gray RG, Gottlieb NL. Intra-articular corticosteroids. Clin Orthop. 1983;177:235
PUBMED
87. Alarcon-Segovia D. Ward LE. Marked destructive changes occurring in osteoarthritic finger joints after intraarticular injection of corticosteroids. Arthritis Rheum. 1966;9:443.
PUBMED
88. Miller WT, Restifo RA. Steroid arthropathy. Radiology. 1966;86:652.
PUBMED
89. Moskowitz RW, Davis W, Sammarco J. Experimentally induced corticosteroid arthropathy. Arthritis Rheum. 1970;134:236.
90. Jones AC, Berman P, Doherty M. Nonsteroidal anti-inflammatory drug usage and requirement in elderly acute hospital admissions. Br J Rheumatol. 1992;31:45-48.
FREE FULL TEXT
91. Swift GL, Rhodes J. Are non-steroidal antiinflammatory drugs always necessary? a general practice survey. Br J Clin Pract. 1992;46:92-94.
PUBMED
92. Huskisson EC, Woolf DL, Balme HW, Scott J, Franklyn S. Four new anti-inflammatory drugs: responses and variations. BMJ. 1976;1:1048-1049.
FREE FULL TEXT
93. Wasner C, Britton MC, Kraines RG, Kaye RL, Bobrove AM, Fries JF. Nonsteroidal anti-inflammatory agents in rheumatoid arthritis and ankylosing spondylitis. JAMA. 1981;246:2168-2172.
FREE FULL TEXT
94. Pincus T, Marcu SB, Callahan LF, et al. Longterm drug therapy for rheumatoid arthritis in seven rheumatology private practices, I: nonsteroidal anti-inflammatory drugs. J Rheumatol. 1992;19:1874-1884.
PUBMED
95. Gall EP, Caperton EM, McComb JE, et al. Clinical comparison of ibuprofen, fenoprofen, calcium, naproxen and tolmetin sodium in rheumatoid arthritis. J Rheumatol. 1982;9:402-407.
PUBMED
96. Abramowicz M, ed. The Medical Letter on Drugs and Therapeutics. 31st ed. New York, NY: The Medical Letter Inc; 1989:31-34. 97. Henry D, Dobson A, Turner C. Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs. Gastroenterology. 1993;105:1078-1088.
PUBMED
98. Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994;343:769-772.
PUBMED
99. Langman MJS, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994;343:1075-1078.
PUBMED
100. Gotzsche PC. Review of dose-response studies of NSAIDs in rheumatoid arthritis. Dan Med Bull. 1989;36:395-399.
PUBMED
101. Seideman P, Samuelson P, Neander G. Naproxen and paracetamol compared with naproxen only in coxarthrosis: increased effect of the combination in 18 patients. Acta Orthop Scand. 1993;64:285-288.
PUBMED
102. Kvien TK, Brors O, Staff PH, Rognstad S, Nordby J. Improved cost-effectiveness ratio with a patient self-adjusted naproxen dosing regimen in osteoarthritis treatment. Scand J Rheumatol. 1991;20:280-287.
PUBMED
|