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Human Papillomavirus Infection
Barbara D. Reed, MD, MSPH;
Philip Zazove, MD
University of Michigan Medical Center Ann Arbor
Arch Fam Med. 1994;3(10):855-856.
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We read with great interest the Editorial by Newkirk1 in the December 1993 issue of the ARCHIVES in which he responded to our two articles,2,3 in the same issue, on human papillomavirus (HPV) detection in low-risk women. While we agreed with most of his comments, we would like to respond to his statements regarding the use of the polymerase chain reaction (PCR) test for the detection of women at a high risk for cervical lesions.
Newkirk stressed that the Papanicolaou test lacks sensitivity for the detection of precancerous lesions of the uterine cervix. We agree. Our research indicates that 13% to 25% of women in the community are infected with HPV when the PCR method is used, and that approximately half of these women have low-grade squamous intraepithelial lesions demonstrated on specimens from colposcopydirected biopsy. Only 10% of these lesions were detected with cytologic screening, and none with
. . . [Full Text PDF of this Article]
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