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Multicenter Comparison of Clarithromycin and Amoxicillin
George S. Rust, MD, MPH
Morehouse School of Medicine Atlanta, Ga
Arch Fam Med. 1994;3(7):574-575.
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The study by Calhoun and Hokanson1 clearly demonstrates that amoxicillin is clinically as effective and as well tolerated as clarithromycin in the treatment of acute maxillary sinusitis. In fact, there is a trend toward higher rates of radiographic clearance in the amoxicillin group (P=.064). Calhoun and Hokanson acknowledged a 26% risk of a type II error (ie, failing to reject the null hypothesis when a significant difference truly exists), given their sample size. A more traditional β value of 20% would have required a larger sample size, and the same difference in radiographic clearance rates between the two antibiotics (78% vs 92%) would most likely have been significantly (P<.05) in favor of amoxicillin. This stands in contrast to the reports of widespread β-lactam resistance among commonly isolated organisms such as Haemophilus influenzae and Moraxella catarrhalis,2 which suggest that in vitro resistance may not necessarily predict the
. . . [Full Text PDF of this Article]
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