Finding Homes for Orphan Cytochrome P450s: CYP4V2 and CYP4F22 in Disease States
Figure 6
Ichthyoses and the hepoxilin lipoxygenase pathway
Steps where genetic mutations are linked to ichthyoses are illustrated. Mutations in either ALOX12B or ALOXE3 result in nonbullous congenital ichthyosiform erythroderma (NCIE), also referred to as type 5 lamellar ichthyosis. We speculate that CYP4F22 could modulate hepoxilin/trioxilin bioactivity in type 3 lamellar ichthyosis as indicated. (The omega position is highlighted in each case, suggesting a role for CYP4F22.)
