The GoLoco Motif: Heralding a New Tango Between G Protein Signaling and Cell Division

Perturbation of heterotrimeric G protein formation by GoLoco-motif peptides. Minimal peptides derived from GoLoco proteins could be used to disrupt the Gαβγ heterotrimer in the absence of GPCR activation. The binding of GoLoco peptides to Gα•GDP precludes Gβγ binding, thus allowing specific activation of Gβγ effectors without concomitant signaling from effectors modulated by Gα•GTP.