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Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy
Table 2.
Selection of Possible Targets for Tumor Therapy by siRNAs
| Genes or Fusion Genes | Aberration | Tumors |
|---|---|---|
| RAS | Point mutations | Pancreatic carcinoma, chronic leukemia, colon carcinoma, lung cancers |
| c-MYC, N-MYC | Overexpression, translocation, Point mutation, amplification | Burkitt’s lymphoma, neuroblastoma |
| ERBB | overexpression | Breast cancer |
| ERBB2 | Overexpression | Breast cancer |
| MLL fusion genes | Translocation | Acute leukemias |
| BCR-ABL | Translocation | Acute and chronic leukemia |
| TEL-AML1 | Translocation | Childhood acute leukemia |
| EWS-FLI1 | Translocation | Ewing sarcoma |
| TLS-FUS | Translocation | Myxoid liposarcoma |
| PAX3-FKHR | Translocation | Alvelolar rhabodomyosarcoma |
| BCL-2 | Overexpression, translocation | Lung cancers, Non-Hodgkin lymphoma, prostate cancer |
| AML1-ETO | Translocation | Acute leukemia |
