Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling

Sequence alignment of the adenylyl and guanylyl cyclases. The catalytic domains (yellow) display considerable similarity in amino acid sequence and have been coined the Cyclase Homology Domain (CHD). Illustrated in light blue are the membrane-spanning regions as predicted from amino acid sequence. (TM, transmembrane; ANP, atrial natriuretic factor; KHD, kinase homology domain.) Adapted from Wedel and Garbers (96).