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Knockout Mouse Points to Second Form of Tryptophan Hydroxylase
Figure 2.
Alignment of the predicted amino-acid sequences o1 TPH1 and TPH2 from man, mouse and rat. Comparison of the sequences of TPH1 to TPH2 within each species reveals amino-acid identities of 72%, 68%, and 70% for man (hs), mouse (mus), and rat (rat), respectively. (Reprinted with permission from Walther et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299, 76 (Supplementary material) (2003). American Association for the Advancement of Science.)
