Figure 2.
GAL plasticity in the basal forebrain nucleus basalis in AD. A. Photomicrograph shows a magnocellular cholinergic nucleus basalis neuron immunostained with the CBF neuronal marker p75NTR (brown reaction product) and innervated by GAL-ir fibers (dark blue reaction product) in aged control brain. The GAL-ir parvicellular
neuron contacting the CBF neuron is visible. B. The photomicrograph shows striking hyperinnervation of GAL fibers impinging upon a nucleus basalis CBF neuron in AD.