Galanin in Alzheimer Disease

GAL innervation of basal forebrain HDB following immunolesion with the selective cholinergic cell toxin 192IgG–saporin. Photomicrograph of ipsilateral lesioned HDB shows p75^NTR-ir CBF neurons (brown reaction product; arrowhead) and p75^NTR-ir CBF neurons containing heavy deposits of GAL immunoreactivity (dark blue reaction product; arrow). The beaded and punctate dark blue deposits resembling GAL-ir axons and terminals covering some of the p75^NTR-ir dendrites are visible. Scale bar = 50 mm.