Estrogen Signaling: A Subtle Balance Between ERα and ERβ

Schematic representation of human estrogen receptor α and β and their respective isoforms. Note that both hERβ2 and hERβΔ5 can have either the hERβ1 long or the short N-termini. In addition, there is no evidence of full-length hERβ4 or hERβ5. The different fill patterns of the 3′ end of hERβ2, 4, and 5 represent the divergent C-terminal regions of these isoforms.