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The Biology of Caveolae: Lessons from Caveolin Knockout Mice and Implications for Human Disease
Figure 4.
Tumorigenesis in Cav-1 −/− mice. Repeated dermal exposure to DMBA results in significantly higher rates of tumor formation (arrows) in Cav-1−/− mice (A), relative to wild-type mice (B). Insets demonstrate the increased epidermal cell hyperplasia of both the basal and suprabasal cell layers prior to tumor formation in animals that lack Cav-1.
