Sodium-Dependent Neurotransmitter TRANSPORTERS: OLIGOMERIZATION as a Determinant of Transporter Function and Trafficking

Schematic representation of DAT as a dimer of dimers. Each circle represents a DAT molecule, with four molecules in a homotetramer numbered 1–4. The squares represent one symmetrical interface (i.e., Cys306). The triangles represent a second interface (i.e., Cys243). Note in the left that the triangles in molecules 1 and 4 do not exist at a symmetrical interface, whereas the triangles in molecules 2 and 3 do so. Squares in all molecules can crosslink. To the right, another set of dimers is shown shaded in gray as they might exist in an array, and in this case both symmetrical interfaces can be repeated within in the array. Reproduced from (36).