Short and Sweet: Evolution of a Small Glycopeptide from a Bladder Disorder to an Anticancer Lead

The structural elements important for APF’s activity. Structural features of the peptide portion of as-APF needed for activity as determined by SAR (9). Groups of amino acids are highlighted in colored boxes and a brief statement concerning their importance is annotated. A synopsis of the SAR that led to Figure 2⇓ (determined through the synthesis and biological evaluation of thirty-six analogs) is given in Box 1. Reprinted with permission.