PHD Fingers: Epigenetic Effectors and Potential Drug Targets

PHD fingers as epigenetic effectors. Shown are the PHD fingers and associated complexes that recognize A) H3K4me3 (orange triangle) or unH3 (yellow bar) and B) other PTMs (including H3 methylated at both Arg² (R2me2, salmon hexagon) and Lys⁴ (K4me3, orange triangle) and H3K9me3 or H3K9ac (taupe oval or blue rectangle). Complexes are colored by their function as promoters of gene activation (green), repression (pink), or recombination (purple).