HETEROCYCLES
An International Journal for Reviews and Communications in Heterocyclic ChemistryWeb Edition ISSN: 1881-0942
Published online by The Japan Institute of Heterocyclic Chemistry
Special Issue
Gilbert Stork's Special Issues, Vol. 25, No. 1, 1987
Published online:
■ Studies in Plant Tissue Sulture. The Synthesis and Biosynthesis of Indole Alkaloids
James P. Kutney
*Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, B.C., V6T 1Z1, Canada
Abstract
A summary of recent studies with various plant tissue cultures obtained from Catharanthus roseus is presented. The main emphasis of the research program concerns the propagation of stable cell lines for the production of the alkaloids catharanthine, vinblastine and vincristine. Related to these objectives are studied on the biosynthesis and biotransformation of 3’,4’-anhydrovinblastine (26) in order to provide a better understanding of the enzymatic production of the above-mentioned bisindole alkaloids. Isolation of cell free extracts (crude enzyme mixtures) from such cultures and studies with these extracts are also presented.
Published online:
■ Hydroboration of Heterocycles Olefins — A Versatile Route for the Synthesis of Both Racemic and Optically Active Heterocyclic Compounds
Herbert C. Brown and J. V. N. Vara Prasad
*Richard B. Wetherill Laboratory, Purdue University, West Lafayette, Indiana 47907-1393, U.S.A.
Abstract
The hydroboration of representative types of heterocyclic olefins with various hydroborating agents, viz., borane-methyl sulfide, 9-borabicyclo[3.3.1]nonane, dicyclohexylborane and disiamylborane, is described. The synthesis of heterocyclic derivatives of high enantiomeric purity via asymmetric hydroboration of heterocyclic olefins with chiral hydroborating agents is also reviewed. The preparation and isolation of heterocyclic boronates of essentially 100% ee is also discussed, as well as the probable range of utilization of these derivatives for the asymmetric synthesis of optically pure enantiomeric heterocyclic derivatives.
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■ Syntheses of Indolizidine Alkaloids — A Review
Sundaramoorthi Rajeswari, Sundaram Chandrasekharan, and Tuticorin R. Govindachari
*Research and Development Laboratory, Amrutanjan Limited, Mylapore, Madras-600 004, India
Abstract
Synthetic approaches to the indolizidine alkaloids as well as chiral syntheses of some members of this group published during 1979-1985 are reviewed.
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■ Review of Synthetic Studies toward CC-1065, PDE-I, and PDE-II
Viresh H. Rawal, Robert J. Jones, and Michael P. Cava
*Department of Chemistry, University of Alabama, Box 870336, University, Tuscaloosa, Alabama 35478-0336, U.S.A.
Abstract
The synthetic approaches to the potent antitumor agent CC-1065 (1) and the closely related phosphodiesterase inhibitors PDE-I (2) and PDE-II (3) are reviewed.
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■ Enantioselective Syntheses of Carbapenem Antibiotics
Takayasu Nagahara and Tetsuji Kametani
*Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
Abstract
A family of carbapenem antibiotics, represented by thienamycin, exhibits strong and broad antibacterial activities. In this review, recent enantioselectlve syntheses of naturally occurring carbapenems are summarized as a main subject.
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■ Advances in the Chemistry of the Furanoditerphenoids from Teucrium Species
Franco Piozzi, Benjamin Rodriguez, and Giuseppe Savona
*Dipartimento di Chimica Organica, Università digli Studi di Palermo, Via Archirafi 20 90123 Palermo, Italy
Abstract
This reviev describes the major advances reported during the last five years on the chemistry of these diterpenoids.