CASE REPORT |
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Year : 2011 | Volume
: 17
| Issue : 3 | Page : 235-237 |
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Acute promyelocytic leukemia with unusual karyotype
Mangala Gowri1, SK Kousar Jahan1, Kavitha1, Prasannakumari1, Madhumathi2, L Appaji3
1 Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore - 560029, India 2 Heamatology Unit, Kidwai Memorial Institute of Oncology, Bangalore - 560029, India 3 Department of Pedotric Oncology, Kidwai Memorial Institute of Oncology, Bangalore - 560029, India
Correspondence Address:
Prasannakumari Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore - 560 029, Karnataka India
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DOI: 10.4103/0971-6866.92093
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Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21:), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML). |
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