Figure 1: Pedigree of a multiplex familial Mediterranean fever (FMF) family (three cases), proband is a male 12 years old genotyped M694V/M680I, started to complain at the age of 9.5 years. There is positive consanguinity. His uncle is genotyped homozygous M694V; his aunt is genotyped M694V/V726A. So, allele M694V is common in all affected members. Empty squares and circles are no-tested, filled squares and circles are symptomatic FMF cases