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Figure 1: Schematic representation of the strategy used to selectively amplify genetic regions harboring polymorphisms for sequencing. (a) MYBPC3 - rs36212066 (25 bp deletion, intron 32),b) SLCO1B1 - rs4149056 (c. 521T > C, exon 6),c) VKORC1 - rs9923231 (c.−1639 G > A, promoter)d) CYP2C9 alleles, - CYP2C9*13 - rs72558187 (c. 269T > C, exon 2), CYP2C9*2-rs28371674 (c. 430C > T, exon 3) and CYP2C9*3 rs1057910 (c. 1075A > C, exon 7), (e) CYP2C19 alleles, - CYP2C19*3 rs4986893 (c. 636G > A, exon 4) and CYP2C19*2 rs4244285 (c. 681G > A, exon 5) |
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