BoneKEy Reports | Reviews

HIF-1α and growth plate development: what we really know

Ernestina Schipani
Laura Mangiavini
Christophe Merceron

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DOI:10.1038/bonekey.2015.99

Abstract

Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1α in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation.

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