Journal Facts

Journal
BoneKEy Reports
ISSN
2047-6396
Volume
5
Year
2016

Article Facts

Title
Osteoimmunology: from mice to humans
DOI
10.1038/bonekey.2016.29
Authors

Patrizia D’Amelio
Francesca Sassi

Online Date
05/18/2016

Article Links

bonekey Reports | Reviews

Osteoimmunology: from mice to humans

Patrizia D’Amelio
Francesca Sassi


DOI:10.1038/bonekey.2016.29

Abstract

The immune system has been recognized as one of the most important regulators of bone turnover and its deregulation is implicated in several bone diseases such as postmenopausal osteoporosis and inflammatory bone loss; recently it has been suggested that the gut microbiota may influence bone turnover by modulation of the immune system. The study of the relationship between the immune system and bone metabolism is generally indicated under the term ‘osteoimmunology’. The vast majority of these studies have been performed in animal models; however, several data have been confirmed in humans as well: this review summarizes recent data on the relationship between the immune system and bone with particular regard to the data confirmed in humans.

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