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Safe Discontinuation of Antihypertensive Therapy
Julienne K. Kirk, PharmD;
Scott H. Johnson, MD
Arch Fam Med. 1995;4(3):266-270.
Abstract
We summarize herein the clinical and pathophysiological features of antihypertensive withdrawal syndrome and its risk factors, management, and prevention. Antihypertensive withdrawal syndrome occurs most frequently with β-blocking agents and centrally acting antihypertensives such as clonidine hydrochloride. This syndrome resembles a state of sympathetic nervous system hyperactivity. In the most critical case, it can be severe and life threatening. Antihypertensive dosages, particularly for β-blockers and clonidine, should be tapered slowly rather than discontinued abruptly.
Author Affiliations
From the Department of Family and Community Medicine, Bowman Gray School of Medicine, Winston-Salem, NC (Dr Kirk), and the Department of Family Medicine, Oregon Health Sciences University, Portland (Dr Johnson).
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