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Successful Management of Refractory Hypertension With Dual Calcium Channel Blocker TherapyCase Presentation
Kristi Geurian, PharmD;
David Lipschitz, MD, PhD
Arch Fam Med. 1997;6(5):503-505.
Abstract
Dual calcium channel blocker therapy seems to be safe and effective for the treatment of refractory hypertension. Nondihydropyridine calcium channel blockers (verapamil and diltiazem hydrochloride) exert their antihypertensive effects by decreasing cardiac output via negative inotropic and negative chronotropic activity and by peripheral vasodilation. Dihydropyridine calcium channel blockers exert their antihypertensive effects via potent peripheral vasodilation. Based on the above properties, synergistic lowering of blood pressure is possible with combined nondihydropyridine plus dihydropyridine calcium channel blocker therapy. The adverse effect profile of dual calcium channel blocker therapy is attractive due to the lack of effect on cholesterol and blood glucose levels, mood, exercise tolerance, and sexual function reported with many of the available antihypertensive options.
Author Affiliations
From the Departments of Pharmacy Practice (Dr Geurian) and Geriatrics (Dr Lipschitz), University of Arkansas for Medical Sciences, Little Rock.
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