Figure 1. Middle ear isolates from rural Kentucky children with acute otitis media, 1992 to 1994 (N=283). Plus sign indicates 
-lactamase positive; minus sign, -lactamase negative; asterisk, minimum inhibitory concentration (MIC) 
2.0 µg/mL; dagger, MIC >0.06-1.0 µg/mL; and double dagger, MIC 
0.06 µg/mL (reproduced from Block et al,3 with permission).
