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Figure 1. Middle ear isolates from rural Kentucky children with acute otitis media, 1992 to 1994 (N=283). Plus sign indicates {beta}-lactamase positive; minus sign, {beta}-lactamase negative; asterisk, minimum inhibitory concentration (MIC) >= 2.0 µg/mL; dagger, MIC >0.06-1.0 µg/mL; and double dagger, MIC <=0.06 µg/mL (reproduced from Block et al,3 with permission).