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Brief Treatment and Crisis Intervention 3:275-290 (2003)
© 2003 Oxford University Press

Biological, Pharmacological, and Somatic Treatments for Obsessive-Compulsive Disorder

   Michele T. Pato, MD
   Katharine A. Phillips, MD

From the Department of Psychiatry at SUNY Upstate Medical University and the Center for Psychiatric and Molecular Genetics and VAMC Syracuse (Pato) and the Department of Psychiatry and Human Behavior at the Brown University School of Medicine and the Body Dysmorphic Disorder Program at Butler Hospital (Phillips).

Contact author: Michele T. Pato, MD, 750 East Adams Street, IHP, Center for Psychiatric and Molecular Genetics, Syracuse, New York 13210. E-mail: cmpato{at}aol.com.

For many patients, obsessive-compulsive disorder is a lifelong illness extending from early childhood into adulthood. However, pharmacological and behavioral treatments at adequate doses and duration offer a majority of patients improvement in symptoms and functioning. At the present time, there are a number of effective medications with relatively tolerable side effects. Experimental biological treatments for the truly treatment refractory, such as neurosurgery, deep brain stimulation, and vagal nerve stimulation, are being developed and refined, and may ultimately offer new hope to patients who do not respond to traditional treatments. [Brief Treatment and Crisis Intervention 3:275–290 (2003)]

KEY WORDS: pharmacotherapy, serotonin, obsessions, compulsions, neuroimaging, neurochemical, serotonin reuptake inhibitors, SRIs, treatment refractory, neurosurgery






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