Figure 1.
The NRSE–NRSF system.
A. Consensus sequence of the NRSE deduced from functional analysis of silencer elements in nineteen genes (57). Nucleotides in lower case vary frequently among functional silencer elements. B. Domains of the NRSF protein (also known as REST).C. REST4 is a C-terminally truncated splice variant of the NRSF protein.