Pharmacology of Store-operated Calcium Channels

Monster Icrac resulting from overexpressed STIM1 and Orai1. In HEK293 cells overexpressing STIM1 and Orai1, IP₃ causes the development of large inward currents with the properties of I_crac. The time course of inward current development is compared to control (A), and the I_crac-like current–voltage relationship is shown (B). Maximum I_crac from the RBL cell line, one of the greatest natural I_crac currents, is shown by the dotted line for comparison. Adapted from (22).