Regulation of ABC Transporters at the Blood-Brain Barrier: New Targets for CNS Therapy
Figure 1
The blood-brain barrier (BBB)/neurovascular unit. The neurovascular unit comprises four cell types: capillary endothelial cells, pericytes, astrocytes, and neurons. The cells are integrated into one cell complex that controls critical BBB functions. The figure also shows the localization of the ABC drug efflux transporters P-glycoprotein (P-gp), BCRP (breast cancer resistance protein), and MRPs (multidrug resistance associated-proteins).
