Figure 5
Targeting BBB P-glycoprotein in Alzheimer’s disease (AD). Proposed two-step Aβ clearance mechanism involving LRP1 (low-density lipoprotein receptor-related protein 1) in the abluminal
membrane and P-glycoprotein in the luminal membrane of brain capillary endothelial cells. Ligand-activation of PXR restores
blood-brain barrier P-glycoprotein in an AD mouse model and lowers Aβ brain levels.