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LuXuRies of Lipid Homeostasis: The Unity of Nuclear Hormone Receptors, Transcription Regulation, and Cholesterol Sensing
Figure 1.
Characterization of oxysterol receptors LXRα and LXRβ.
A. Tissue distribution of LXRα and LXRβ. Shown is a gel blot analysis of adult male mouse tissue mRNA (5μg) probed with DNA fragments that encode sequences of LXRα, LXRβ, or cyclophilin as control.
B. The consensus DNA sequence that defines the LXR response element (LXRE) to which functional LXRs bind to promote transcription. The LXRE consists of a direct repeat of the indicated hexanucleotide sequence separated by four bases.
