p53 Moves Into Control of Cell Morphology

Role of Rho proteins in cell motility. A. Chemotactic stimuli can promote Cdc42-dependent microspikes that can be suppressed by activation of p53. Microspikes can promote the formation of contacts between the cell and the substratum and cell spreading. B . Microspikes precede the formation of larger Rac1-dependent membrane protrusions that drive cell movement. Cdc42 activity is required to orient the Golgi apparatus in the direction of movement; the activation of p53 prevents this process. RhoA promotes the generation of the contractile force that is required to move the remaining part of the cell behind the protrusion.