GIRK Channel Trafficking: Different Paths for Different Family Members

Kir3/GIRK channel trafficking. A. Diagram showing the topology of Kir channels and the location of the domains identified by Ma et al. (15) that play important roles in Kir3 channel trafficking. B. Schematic representation of the localization of different channel subunits (Kir3.1—Kir3.4). Channels and cell compartments are color coded. Combinations of only two subunits (rather than four) are shown for purposes of illustration. Kir, inwardly rectifying K⁺ channels; GIRK, G protein-regulated inwardly rectifying channels; TM, transmembrane; P, P-region; TGN, trans Golgi network.