Phospholipase C–γ1: A Phospholipase and Guanine Nucleotide Exchange Factor

Organization of domains in PLC–γ1 and their interaction with other proteins and lipids. X and Y are catalytic domains of PLC–γ 1. PH, pleckstrin homology domain; PIP₃ , phosphatidylinositol-3,4,5-trisphosphate; PIP₂ , phosphatidylinositol-4,5-bisphosphate; Pro, proline-rich regions of various proteins; IP₃ ; inositol trisphosphate; RTKs, growth factor receptor tyrosine kinases; pY, phosphotyrosine; DAG, diacylglycerol; SH2, Src homology 2 domain; SH3, Src homology 3 domain.