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The “Heartbreak” of Older Age
Table 3.
Pufa And Phospholipid Content In Mitochondrial Membranes From Young And Old Rat Hearts
| Diet | ω6 PUFA | ω3 PUFA | ||
|---|---|---|---|---|
| Age (months) | 6 | 24 | 6 | 24 |
| Membrane PUFA values are expressed as mol/100mol (mean ± SEM, n=5). Phospholipid values are expressed as % of total mitochondrial phospholipids. DPG, diphosphatidyl glycerol (cardiolipin); PC, phosphatidylcholine; PE, phosphatidyl ethanolamine; PI, phosphatidylinositol; PS, phosphatidylserine. | ||||
| * = P< 0.05 vs. 6 month old; † =P <0.05 vs. ω6 PUFA. See (31) for individual PUFA details. | ||||
| Total fatty acids | ||||
| sum of ω6 PUFA | 42.1 ± 0.85 | 44.6 ± 1.58 | 21.3 ± 0.50† | 1.1 ± 0.33† |
| sum of ω3 PUFA | 11.3 ± 0.69 | 3.1 ± 1.44* | 37.1 ± 1.1† | 42.2 ± 1.35† |
| Phospholipids | ||||
| DPG | 12 ± 0.4 | 8.5 ± 0.4* | 15 ± 0.9 | 14 ± 0.8† |
| PC | 46 ± 0.7 | 53 ± 0.7* | 42 ± 1.8 | 42 ± 1.6† |
| PE | 35 ± 0.8 | 33 ± 0.6 | 3 ± 0.8 | 40 ± 0.8 |
| PS | 2.4 ± 0.3 | 2.5 ± 0.2 | 2.2 ± 0.1 | 2.4 ± 0.1 |
| PI | 1.3 ± .01 | 1.4 ± 0.1 | 1.1 ± 0.2 | 1.2 ± 0.3 |
