AMPA Receptor Trafficking: A Road Map for Synaptic Plasticity

Trafficking of AMPARs along cytoskeletal tracks. The movement of AMPARs through the dendritic shaft along the microtubular cytoskeleton requires the interaction between the GluR2 C-terminus and the PDZ protein GRIP/ABP, which is connected to the motor protein KIF1 through liprin-α. The connection of the AMPARs with the actin cytoskeleton at dendritic spines may be mediated by protein 4.1N, which interacts with the actin–spectrin filaments and with GluR1 and GluR4 subunits.