Probing the World of Cytochrome P450 Enzymes

Table 3.

Selected Nonsynonymous Polymorphisms in CYP Enzymes and the Functional Consequence

Enzyme Common Allelic Variant Amino Acid Substitution Effect on Enzyme Function
CYP2A6 CYP2A6*2 Leu160His Decreased
CYP2B6 CYP2B6*5 Arg487Cys Unchanged
CYP2B6*6 Gln172His, Lys262Arg Increased
CYP2B6*7 Gln172His, Lys262Arg, Arg487Cys Increased
CYP2C8 CYP2C8*2 Ile269Phe Decreased
CYP2C8*3 Arg139Lys, Lys399Arg Decreased
CYP2C9 CYP2C9*2 Arg144Cys Altered affinity
CYP2C9*3 Ile359Leu Decreased
CYP2C9*5 Asp360Glu Decreased
CYP2D6 CYP2D6*10 Pro34Ser, Ser486Thr Decreased
CYP2D6*17 Thr107Ile, Arg296Cys, Ser486Thr Decreased
CYP2E1 CYP2E1*2 Arg76His Decreased

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  1. MI June 2004 vol. 4 no. 3 157-162
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