ROLE of MITOCHONDRIA in TOXIC OXIDATIVE STRESS

Mitochondrial DNA and oxidative stress. A. Mitochondrial genome from human cells indicating the genes, and some mitochondrial mutations associated with human disease. Mitochondrial DNA Map http://www.gen.emory.edu/mitomap.htmlB. Role of mtDNA in oxidative stress–induced injury. MtDNA damage can lead to loss of expression of mitochondrial polypeptides, subsequent decrease in electron transport and increased generation of reactive oxygen species (ROS), loss of mitochondrial membrane potential, and release of signals for cell death, such as cyt c and apoptosis-inducing factor (AIF).