SEROTONIN 5-HT_2C RECEPTOR AGONISTS: POTENTIAL FOR THE TREATMENT OF OBESITY

Metabolic peculiarities of mice lacking the serotonin 5-HT_2Creceptor. A. The knockout mice (purple)manifest late-onset obesity, weighing thirty percent more than their wild-type litter mates (yellow)after forty-two weeks of age. B. In addition to being hyperphagic, the knockout mice exhibit metabolic hormone changes including the development of hyperleptinemia and hyperinsulinemia. Data reproduced with permission from (62). Copyright Nature Publishing Group 1998.