BCL-xL Regulates Synaptic Plasticity

Synaptic potentiation requires mitochondria. A. A diagram of changes in postsynaptic potentials and presynaptic calcium levels during and after tetanic stimulation to the presynaptic cell. B. In the absence of mitochondria, the prolonged tail of residual calcium observed after the tetanus is not apparent and posttetanic potentiation is inhibited. C. Re-release of calcium from mitochondria inside the presynaptic terminal controls short-term synaptic plasticity.