Bound to Be Different: Neurotransmitter Transporters Meet Their Bacterial Cousins

Cl⁻ binding site in hSERT. Illustration depicts hSERT labeled helices (TM) and residue side chains identified by Forrest et al. (1) to coordinate Cl⁻ binding in the human serotonin transporter (hSERT) (stick rendering). The Cl⁻ (red) and Na⁺ (blue) ions are shown as labeled spheres. The figure was generated in Pymol (DeLano Scientific LLC, San Carlos,. California) using coordinates from a LeuT_Aa-hSERT homology model we have developed in our studies.