Transporter Regulation by Polyunsaturated Fatty Acidsa
Transporter | Fatty acid (structure) | Regulationb | Ref. |
---|---|---|---|
Rat GAT |
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Transport inhibited | 25, 26, 33 |
Rat GLT-1/GLAST/EAAC1 | Arachidonic acid | Vmax decreased | 25–31, 36 |
Rat GLT-1 |
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Vmax decreased | 33 |
Rat EAAT4 | Arachidonic acid Arachidonic acid | I increased, H+ conductance | 38 |
Human EAAT1 |
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ITransport decreased | 35 |
Human EAAT2 | A-Linolenic acid Linoleic acid | ITransport increased, Km decreased | 35 |
Human EAAT3 | Arachidonic acid Arachidonic acid A-Linolenic acid | ITransport increased, Km decreased | 35 |
Human EAAT4 | Linoleic acid Docosahexanoeic acid Oleic acid | I increased, H+ conductance | 37 |
Salamander GLT1/GLAST | Arachidonic acid Oleic acid | Vmax decreased | 32 |
Rat DAT | Arachidonic acid | Transport inhibited Vmax decrease, Km decrease | 41 |
Human DAT | Arachidonic acid | I increased, Cation conductance | 42, 44 |
Rat Na+/K+-ATPase | Arachidonic acid | Transport inhibited | 25 |