| ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 17
| Issue : 3 | Page : 175-178 |
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Association of CYP3A5*3 polymorphism with development of acute leukemia
D Nageswara Rao1, G Manjula1, K Sailaja1, D Surekha1, D Raghunadharao2, Senthil Rajappa2, S Vishnupriya1
1 Department of Genetics, Osmania University, Hyderabad, India
2 Department of Genetics, Nizams Institute of Medical Sciences, Hyderabad, India
Correspondence Address:
S Vishnupriya
Department of Genetics, Osmania University, Hyderabad
India
 Source of Support: UGC and Department of Medical Oncology, Nizams institute of Medical Sciences, Hyderabad, India., Conflict of Interest: None  | 4 |
DOI: 10.4103/0971-6866.92098
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Background : CYP3A5 was observed to be an important genetic contributor to inter individual differences in CYP3A-dependent drug metabolism in acute leukemic patients. Loss of CYP3A5 expression was mainly conferred by a single nucleotide polymorphism at 6986A>G (CYP3A5*3). We investigated the association between CYP3A5*3 polymorphism and acute leukemia.
Materials and Methods : Two hundred and eighty nine acute leukemia cases comprising of 145 acute lymphocytic leukemia (ALL), 144 acute myeloid leukemia and 241 control samples were analyzed for CYP3A5*3 polymorphism using PCR-RFLP method. Statistical analysis was performed with SPSS version (15.0) to detect the association between CYP3A5*3 polymorphism and acute leukemia.
Results : The CYP3A5*3 polymorphism 3/3 genotype was significantly associated with acute leukemia development (χ2 - 133.53; df-2, P 0.000). When the data was analyzed with respect to clinical variables, mean WBC, blast % and LDH levels were increased in both ALL and AML cases with 3/3 genotype. The epidemiological variables did not contribute to the genotype risk to develop either AML or ALL.
Conclusion : The results suggest that the CYP3A5*3 polymorphism might confer the risk to develop ALL or AML emphasizing the significance of effective phase I detoxification in carcinogenesis. Association of the polymorphism with clinical variables indicate that the 3/3 genotype might also contribute to poorer survival of the patients. |
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