CVM Cardiovascular Medicine 1664-204X 1664-2031 EMH Schweizerischer Ärzteverlag AG Farnsburgerstrasse 8 CH-4132 Muttenz 02146 10.4414/cvm.2022.02146 Review article Genetics Role of lifespan-regulating genes in age-related cardiovascular disease Puspitasari Yustina M. Center for Molecular Cardiology, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Schwarz Lena Center for Molecular Cardiology, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Camici Giovanni G. giovannic@access.uzh.ch SWITZERLAND 01 03 2021 24 02 0 0 Copyright: EMH Schweizerischer Ärzteverlag AG 2022 EMH Schweizerischer Ärzteverlag AG "Cardiovascular Medicine" is an open access publication of EMH published in accordance with the terms of the Creative Commons licence attribution - NonCommercial - NoDerivatives 4.0 International. You are free to share, copy and redistribute the material in any medium or format under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. NonCommercial — You may not use the material for commercial purposes. NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material. "Non-commercial" means not primarily intended for or directed towards commercial advantage or monetary compensation. The incorporation of publications in commercial products, the use of publications to advertise for commercial products or services and any other usage that directly or indirectly pursues commercial interests is subject to the express previous consent of the publishing house as part of a written agreement. Please send us your request in writing. Exact indication of the publication from which you would like to reproduce material and detailed information about its intended use help to facilitate and expedite request processing.

An unprecedented increase in human life expectancy has taken place over the past centuries, thus raising the number of elderly people globally. Despite advances in medicine, cardiovascular disease remains the major cause of mortality and morbidity among elderly people and poses a great burden to health care services. As aging is inevitable and represents a risk factor for cardiovascular disease, a better understanding of its underlying mechanism will be crucial to design tailored therapeutic options. Indeed, the dysregulation of aging and longevity genes has been implicated in lifespan by regulating numerous cellular processes, which alter both structural and functional aspects of the cardiovascular system. In this review, several lifespan-determining genes are reviewed, in particular, for their involvement in regulating cardiovascular health via inflammation and oxidative stress. Lastly, several promising prevention and treatment approaches such as an anti-aging and age-associated cardiovascular disease intervention are also described.