<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" "http://jats.nlm.nih.gov/publishing/1.0/JATS-journalpublishing1.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.0" xml:lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">CVM</journal-id>
      <journal-title-group>
        <journal-title>Cardiovascular Medicine</journal-title>
      </journal-title-group>
      <issn pub-type="epub">1664-204X</issn>
      <issn pub-type="ppub">1664-2031</issn>
      <publisher>
        <publisher-name>EMH Schweizerischer Ärzteverlag AG</publisher-name>
        <publisher-loc>Farnsburgerstrasse 8
CH-4132 Muttenz</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">02211</article-id>
      <article-id pub-id-type="doi">10.4414/cvm.2022.02211</article-id>
      <article-categories>
        <!-- rubric -->
        <subj-group subj-group-type="Article Type">
          <subject>Original article</subject>
        </subj-group>
        <!-- topics -->
        <subj-group subj-group-type="Classification">
          <subject>Valvular heart disease</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Early degeneration of the Sorin Mitroflow aortic bioprosthesis</article-title>
      </title-group>
      <contrib-group>
        <contrib id="author-1" contrib-type="author" corresp="yes">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Widmer</surname>
            <given-names>Fritz</given-names>
          </name>
          <email>fr_widmer@bluewin.ch</email>
          <aff>Kantonsspital Muensterlingen | Medizinische Klinik, Kardiologie | Spital Campus 1 | Muensterlingen | 8596 | SWITZERLAND</aff>
        </contrib>
        <contrib id="author-2" contrib-type="author" corresp="no">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Schliephake</surname>
            <given-names>Florian</given-names>
          </name>
          <email/>
          <aff>Internal Medicine, Cardiology, 
Kantonsspital Münsterlingen</aff>
        </contrib>
        <contrib id="author-3" contrib-type="author" corresp="no">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Mattle</surname>
            <given-names>Daniel</given-names>
          </name>
          <email/>
          <aff>Internal Medicine, Cardiology,
Kantonsspital Münsterlingen</aff>
        </contrib>
        <contrib id="author-4" contrib-type="author" corresp="no">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Federmann</surname>
            <given-names>Martin</given-names>
          </name>
          <email/>
          <aff>Cardiology Praxis
Weinfelden</aff>
        </contrib>
      </contrib-group>
      <pub-date pub-type="epub" date-type="pub" iso-8601-date="2022.07.01">
        <day>01</day>
        <month>07</month>
        <year>2022</year>
      </pub-date>
      <volume>25</volume>
      <issue>04</issue>
      <fpage>0</fpage>
      <lpage>0</lpage>
      <permissions>
        <copyright-statement>Copyright: EMH Schweizerischer Ärzteverlag AG</copyright-statement>
        <copyright-year>2022</copyright-year>
        <copyright-holder>EMH Schweizerischer Ärzteverlag AG</copyright-holder>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/">
          <license-p>"Cardiovascular Medicine" is an open access publication of EMH published in accordance with the terms of the Creative Commons licence attribution - NonCommercial - NoDerivatives 4.0 International. You are free to share, copy and redistribute the material in any medium or format under the following terms:</license-p>
          <license-p>Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.</license-p>
          <license-p>NonCommercial — You may not use the material for commercial purposes.</license-p>
          <license-p>NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.</license-p>
          <license-p>"Non-commercial" means not primarily intended for or directed towards commercial advantage or monetary compensation. The incorporation of publications in commercial products, the use of publications to advertise for commercial products or services and any other usage that directly or indirectly pursues commercial interests is subject to the express previous consent of the publishing house as part of a written agreement.</license-p>
          <license-p>Please send us your request in writing. Exact indication of the publication from which you would like to reproduce material and detailed information about its intended use help to facilitate and expedite request processing.</license-p>
        </license>
      </permissions>
      <abstract abstract-type="article" xml:lang="en">
        <p>We report a series of 31 patients after surgically aortic valve implantation of a bovine Sorin Mitroflow bioprosthesis with early severe structural valve degeneration (SVD) despite absence of known risk factors. Half of the patients underwent re-intervention and more than one third died without re-intervention, mostly prematurely due to heart failure caused by SVD. The Sorin Mitroflow valve was prone to early SVD even in very old patients, which may be at least in part due to a lack of anti-calcification treatment and its peculiar design. This led to additional suffering of the patients and added healthcare expense. The inferior durability was largely undetected for almost 2 decades, which in retrospect was mainly because earlier studies relied on SVD diagnosis only at reoperation, reported no regular echocardiographic monitoring and did not consider the competing risk of death despite high mortality rates. To avoid a similar delay in the recognition of specific problems with new surgical valves analogue to the already ongoing TAVR-registries the introduction of mandatory SAVR-registries with regular echocardiographic monitoring and uniform definition of SVD as well as broad training of all cardiologists and echocardiographers involved in SVD screening and treatment seems reasonable.</p>
      </abstract>
    </article-meta>
  </front>
  <body/>
  <back/>
</article>
