SANP Swiss Archives of Neurology, Psychiatry and Psychotherapy 2297-7007 2297-6981 EMH Schweizerischer Ärzteverlag AG Farnsburgerstrasse 8 CH-4132 Muttenz 03355 10.4414/sanp.2023.03355 Case report Mood [affective] disorders Taux de valproate dans le traitement de maintien du trouble ­bipolaire – quel intérêt? Papachristou Christos c.papachristou@hin.ch Chef de clinique | Rue de Lyon 89 | Genève | 1203 | SWITZERLAND | +41789154379 Besson Marie marie.besson@hcuge.ch Service de Pharmacologie et Toxicologiqe cliniques, Hôpitaux Universitaires de Genève, Suisse Bartolomei Javier Service de psychiatrie Adulte, Hôpitaux Universitaires de Genève, Suisse 14 06 2023 174 03 93 94 Copyright: EMH Schweizerischer Ärzteverlag AG 2023 EMH Schweizerischer Ärzteverlag AG "Swiss Archives of Neurology, Psychiatry and Psychotherapy" is an open access publication of EMH published in accordance with the terms of the Creative Commons licence attribution - NonCommercial - NoDerivatives 4.0 International. You are free to share, copy and redistribute the material in any medium or format under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. NonCommercial — You may not use the material for commercial purposes. NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material. "Non-commercial" means not primarily intended for or directed towards commercial advantage or monetary compensation. The incorporation of publications in commercial products, the use of publications to advertise for commercial products or services and any other usage that directly or indirectly pursues commercial interests is subject to the express previous consent of the publishing house as part of a written agreement. Please send us your request in writing. Exact indication of the publication from which you would like to reproduce material and detailed information about its intended use help to facilitate and expedite request processing.

Valproate is an antiepileptic drug that is widely used as a mood stabiliser in the treatment of bipolar disorder, both in the acute phase and as a maintenance treatment. However, due to complex pharmacokinetics, the interpretation of valproate plasma concentrations remains difficult, a point we wish to clarify with a clinical case.