SMF Schweizerisches Medizin-Forum 1424-4020 1424-3784 EMH Schweizerischer Ärzteverlag AG Farnsburgerstrasse 8 CH-4132 Muttenz 08327 10.4414/smf.2019.08327 Der besondere Fall Endokrinologie / Diabetologie und Stoffwechsel Hämatologie Kinder- und Jugendmedizin Medizinische Onkologie Radiologie Schwere Komplikationen einer beta-Thalassaemia major Schneider Christine christine.schneider@insel.ch Pädiatrische Hämatologie | Freiburgstrasse 18 | Bern | 3010 | SWITZERLAND Zingg Tanja tanja.zingg@insel.ch Universitatsklinik fur Kinderheilkunde, Endokrinologie, Diabetologie & Stoffwechsel, Inselspital Bern Slavova Nedelina nedelina.slavova@insel.ch Universitätsinstitut für Diagnostische und Interventionelle Neuroradiologie, Inselspital Bern Diepold Miriam miriam.diepold@insel.ch Universitätsklinik für Kinderheilkunde, Hämatologie & Onkologie, Inselspital Bern Xydias Theodoros theodoros.xydias@insel.ch Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie, Inselspital Bern Flück Christa E. christa.flueck@insel.ch Abteilungsleiterin Pädiatrische Endokrinologie/Diabetologie/Metabolik, Department for BioMedical Research (DBMR) Rössler Jochen Abteilungsleiter Pädiatrische Hämatologie und Onkologie, Inselspital Bern Universitatsklinik fur Kinderheilkunde 04 12 2019 19 4950 818 821 Copyright: EMH Schweizerischer Ärzteverlag AG 2019 EMH Schweizerischer Ärzteverlag AG "Swiss Medical Forum" is an open access publication of EMH published in accordance with the terms of the Creative Commons licence attribution - NonCommercial - NoDerivatives 4.0 International. You are free to share, copy and redistribute the material in any medium or format under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. NonCommercial — You may not use the material for commercial purposes. NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material. "Non-commercial" means not primarily intended for or directed towards commercial advantage or monetary compensation. The incorporation of publications in commercial products, the use of publications to advertise for commercial products or services and any other usage that directly or indirectly pursues commercial interests is subject to the express previous consent of the publishing house as part of a written agreement. Please send us your request in writing. Exact indication of the publication from which you would like to reproduce material and detailed information about its intended use help to facilitate and expedite request processing. <p>Beta-Thalassaemia is caused by a point mutation or deletion that leads to a decreased production of beta-globin, resulting in defective red blood cells and ineffective erythropoiesis. Complications are microcytic hypochromic anaemia, bone marrow expansion and, due to compensation mechanisms, extramedullary haematopoesis and increased intestinal iron absorption. The resulting iron overload may be aggravated by recurrent blood transfusions used for treatment of the anaemia. Today, complications of Beta-Thalassaemia in industrialized countries are rare due to early initiation of regular blood transfusions, chelation therapy and the possibility of curative allogenic stem cell transplantation. We present three clinical cases of refugee adolescents from the middle east with Beta- Thalassaemia who show severe complications due to inadequate therapy during escape from their countries. Details on the management of therapy initiation will be reported as well as first follow-up.</p> <p>COI 7/7 vorhanden - conflicts bei Diepold und R&ouml;ssler!</p>