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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">SMF</journal-id>
      <journal-title-group>
        <journal-title>Schweizerisches Medizin-Forum</journal-title>
      </journal-title-group>
      <issn pub-type="epub">1424-4020</issn>
      <issn pub-type="ppub">1424-3784</issn>
      <publisher>
        <publisher-name>EMH Schweizerischer Ärzteverlag AG</publisher-name>
        <publisher-loc>Farnsburgerstrasse 8
CH-4132 Muttenz</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">09166</article-id>
      <article-id pub-id-type="doi">10.4414/smf.2022.09166</article-id>
      <article-categories>
        <!-- rubric -->
        <subj-group subj-group-type="Article Type">
          <subject>Übersichtsartikel</subject>
        </subj-group>
        <!-- topics -->
        <subj-group subj-group-type="Classification">
          <subject>Hämatologie</subject>
          <subject>Infektiologie</subject>
          <subject>Klinische Pharmakologie und Toxikologie</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Antikoagulation bei COVID-19</article-title>
      </title-group>
      <contrib-group>
        <contrib id="author-1" contrib-type="author" corresp="yes">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Hofmann</surname>
            <given-names>Patrick</given-names>
          </name>
          <email>hofmannpatrick@bluewin.ch</email>
          <aff>Assistenzarzt | Innere Medizin | Loestrasse 170 | Chur | Graubünden | 7000 | SWITZERLAND</aff>
        </contrib>
        <contrib id="author-2" contrib-type="author" corresp="no">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Frenes</surname>
            <given-names>Katharina</given-names>
          </name>
          <email>katharina.frenes@spitaluster.ch</email>
          <aff>Innere Medizin | SWITZERLAND</aff>
        </contrib>
        <contrib id="author-3" contrib-type="author" corresp="no">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Debrunner</surname>
            <given-names>Johann</given-names>
          </name>
          <email>debrunner@gmx.ch</email>
          <aff>Innere Medizin | SWITZERLAND</aff>
        </contrib>
        <contrib id="author-4" contrib-type="author" corresp="no">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Dürst</surname>
            <given-names>Lukas</given-names>
          </name>
          <email>lukas.duerst@ksgr.ch</email>
          <aff>Innere Medizin | SWITZERLAND</aff>
        </contrib>
        <contrib id="author-5" contrib-type="author" corresp="no">
          <contrib-id contrib-id-type="orcid"/>
          <name>
            <surname>Bächli</surname>
            <given-names>Esther</given-names>
          </name>
          <email>esther.baechli@hin.ch</email>
          <aff>Innere Medizin, Klinik St.Anna | SWITZERLAND</aff>
        </contrib>
      </contrib-group>
      <pub-date pub-type="epub" date-type="pub" iso-8601-date="2022.08.16">
        <day>16</day>
        <month>08</month>
        <year>2022</year>
      </pub-date>
      <volume>22</volume>
      <issue>3334</issue>
      <fpage>536</fpage>
      <lpage>541</lpage>
      <permissions>
        <copyright-statement>Copyright: EMH Schweizerischer Ärzteverlag AG</copyright-statement>
        <copyright-year>2022</copyright-year>
        <copyright-holder>EMH Schweizerischer Ärzteverlag AG</copyright-holder>
        <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/">
          <license-p>"Swiss Medical Forum" is an open access publication of EMH published in accordance with the terms of the Creative Commons licence attribution - NonCommercial - NoDerivatives 4.0 International. You are free to share, copy and redistribute the material in any medium or format under the following terms:</license-p>
          <license-p>Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.</license-p>
          <license-p>NonCommercial — You may not use the material for commercial purposes.</license-p>
          <license-p>NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.</license-p>
          <license-p>"Non-commercial" means not primarily intended for or directed towards commercial advantage or monetary compensation. The incorporation of publications in commercial products, the use of publications to advertise for commercial products or services and any other usage that directly or indirectly pursues commercial interests is subject to the express previous consent of the publishing house as part of a written agreement.</license-p>
          <license-p>Please send us your request in writing. Exact indication of the publication from which you would like to reproduce material and detailed information about its intended use help to facilitate and expedite request processing.</license-p>
        </license>
      </permissions>
      <abstract abstract-type="article" xml:lang="de">
        <p>Die mikrozirkulatorische Endotheldysfunktion und Thromboembolien sind zentrale Aspekte in der Pathogenese des respiratorischen Versagens, welches die häufigste Todesursache bei COVID-19 darstellt. Frühe Beobachtungsstudien postulierten eine geringere Krankheitsprogression und einen Überlebensvorteil durch die therapeutische Antikoagulation mit Heparin. Der potentielle therapeutische Nutzen von Heparin liegt neben der Prävention von venösen und arteriellen Thromboembolien in antiviralen und anti-inflammatorischen Eigenschaften. Die folgende Übersichtsarbeit fasst die erfolgten Interventionsstudien zur optimalen Antikoagulation bei moderat und kritisch erkrankten, hospitalisierten sowie ambulanten Patienten mit COVID-19 zusammen.</p>
      </abstract>
    </article-meta>
  </front>
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