The commercial activities of Indian companies in Africa have increased significantly in recent years. Based on anthropological interviews conducted in India, this paper addresses the discursive and commercial dimensions of the contemporary resurgence in Indo-African relations. I first offer a critical examination of discursive strategies inherent to India’s engagement with Africa, which desperately strives to differentiate itself from contending approaches, in particular, that of China. As the paper shows, beyond long-standing claims of (post)colonial solidarity, what distinguishes such an engagement is the contention that a rise in Indo-African commercial activities can, in itself, be considered as a pragmatic form of cooperation. The paper then examines the expansion of the Indian ICTs and medical sectors into Africa. It focuses on the emergence of global techno-medical zones in which data, patients, capital, and knowledge circulate, through practices such as medical tourism and telemedicine. ICTs and healthcare occupy a strategic position in both Indo-African discursive practices and the creation of new market opportunities for an Indian industry eager to flex its economic muscle in the global arena. In critically engaging these concomitant processes, this paper touches the core of India’s distinctive desire to become a major economic power.