ORIGINAL ARTICLE |
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Year : 2013 | Volume
: 19
| Issue : 3 | Page : 291-292 |
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Usage of U7 small nuclear ribonucleic acid in gene therapy of hemoglobin D Punjab disorder: Rationale?
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok-10160, Thailand
Correspondence Address:
Viroj Wiwanitkit Wiwanitkit House, Bangkhae, Bangkok - 10160 Thailand
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DOI: 10.4103/0971-6866.120812
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Background: Hemoglobin (Hb) D Punjab disorder is a congenital hemoglobinopathy described in India. It is a disorder due to defect in beta-globin gene.
Materials and Methods: Here, the author assesses the possibility of U7.623 gene therapy for Hb D Punjab disorder. A standard bioinformatic analysis to study the effect of co-expression between nucleic acid sequence for human Hb D Punjab beta-globin chain and U7.623 was performed.
Result: It can be seen that fully recovery of Hb function and biological process can be derived via gene ontology study.
Conclusion: Here, there is a rationale to use U7 small nuclear ribonucleic acid as a possible tool for gene therapy in Hb D Punjab disorder. |
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